{"id":473,"date":"2023-09-15T20:54:05","date_gmt":"2023-09-15T11:54:05","guid":{"rendered":"https:\/\/igcore.thers.ac.jp\/en\/?post_type=news&#038;p=473"},"modified":"2023-10-19T20:57:06","modified_gmt":"2023-10-19T11:57:06","slug":"473-2","status":"publish","type":"news","link":"https:\/\/igcore.thers.ac.jp\/en\/news\/473-2.html","title":{"rendered":"Designated Professor Morten Thaysen-Andersen and Designated Associate Professor Rebeca Kawahara have published their research results in PNAS."},"content":{"rendered":"<p>Key points of research results\uff1a<\/p>\r\n<ul>\r\n<li><span>The first line of defense in our immune systems are white blood cells, 40% to 70% of which are neutrophils.<\/span> The n<span>eutrophils produce bactericidal glycoproteins during <\/span>their <span>maturation and stores them in cells, and use these bactericidal glycoproteins to promote inflammation and attack invading microbes. <\/span><\/li>\r\n<li><span>The glycan structure of bactericidal glycoproteins was unknown, but as a result of this study, it was found that it is highly unusual glycans. <\/span><\/li>\r\n<li><span>This discovery is a valuable resource for understanding the biological role of the origin of intracellular responses and contributes to the understanding of immune responses in normal people and leukemia patients.<\/span><\/li>\r\n<\/ul>\r\n<p><img src=\"https:\/\/earimediaprodweb.azurewebsites.net\/Api\/v1\/Multimedia\/f0d0422e-d597-4b13-93d8-097552d6f291\/Rendition\/low-res\/Content\/Public\" alt=\"The dynamic neutrophil glycoproteome\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>The results of this research were published in the journal Proceedings of the National Academy of Sciences on August 28, 2023.<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>News Release for the results of this research: <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1003370\">https:\/\/www.eurekalert.org\/news-releases\/1003370<\/a><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\u3010Paper Information\u3011<\/p>\r\n<p>Proceedings of the National Academy of Sciences (PNAS)<\/p>\r\n<p>Glycoproteome remodeling and organelle-specific N-glycosylation accompany neutrophil granulopoiesis<\/p>\r\n<p>DOI Number<a href=\"https:\/\/doi.org\/10.1073\/pnas.2303867120\">: 10.1073\/pnas.230386712 <\/a><br>Publication URL: <a href=\"https:\/\/www.pnas.org\/doi\/suppl\/10.1073\/pnas.2303867120\">https:\/\/www.pnas.org\/doi\/suppl\/10.1073\/pnas.2303867120 <\/a><\/p>","protected":false},"featured_media":151,"parent":0,"template":"","news_cat":[4],"acf":[],"_links":{"self":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news\/473"}],"collection":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/media\/151"}],"wp:attachment":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=473"}],"wp:term":[{"taxonomy":"news_cat","embeddable":true,"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news_cat?post=473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}