{"id":732,"date":"2024-06-27T10:22:47","date_gmt":"2024-06-27T01:22:47","guid":{"rendered":"https:\/\/igcore.thers.ac.jp\/en\/?post_type=news&#038;p=732"},"modified":"2024-06-27T10:22:47","modified_gmt":"2024-06-27T01:22:47","slug":"732-2","status":"publish","type":"news","link":"https:\/\/igcore.thers.ac.jp\/en\/news\/732-2.html","title":{"rendered":"Professor Yasuhiro Kizuka has published their research results in Journal of Biological Chemistry."},"content":{"rendered":"<p><span>Researchers have uncovered how a structure in bodily carbohydrates (sugar chains or <\/span>\u201c<span>glycans<\/span>\u201d<span>) that regulates how they attach themselves to other molecules interacts with key enzymes, and in so doing can contribute to a range of diseases.<\/span><\/p>\r\n<p><span>\u00a0<\/span><\/p>\r\n<p><span>One of the most essential bodily biochemical processes involves carbohydrates (sugan chains or <\/span>\u201c<span>glycans<\/span>\u201d<span>) attaching themselves to proteins and fats (lipids), and when this process malfunctions, the risk of contracting a raft of diseases sharply increases. Researchers have recently discovered how a crucial enzyme<\/span>\u2019<span>s interaction with a small structure in glycans during this attachment can contribute to such breakdowns.<\/span><\/p>\r\n<p><span>Their findings are described in a paper published online in the Journal of Biological Chemistry on June 4th, 2024.<\/span><\/p>\r\n<p><span>\u00a0<\/span><\/p>\r\n<p><span>News Release for this research: <a href=\"https:\/\/www.eurekalert.org\/news-releases\/1049514\">https:\/\/www.eurekalert.org\/news-releases\/1049514<\/a><\/span><\/p>\r\n<p><span>\u00a0<\/span><\/p>\r\n<p>\u3010<span>Paper Information<\/span>\u3011<\/p>\r\n<p><span>Yuko Tokoro, Masamichi Nagae, Miyako Nakano, Anne Harduin-Lepers, Yasuhiko Kizuka.<\/span><\/p>\r\n<p><span>LacdiNAc synthase B4GALNT3 has a unique PA14 domain and suppresses N-glycan capping.<\/span><\/p>\r\n<p><span>Journal of Biological Chemistry, Volume 300, Issue 7, 2024, 107450.<\/span><\/p>\r\n<p><span><a href=\"https:\/\/doi.org\/10.1016\/j.jbc.2024.107450\">https:\/\/doi.org\/10.1016\/j.jbc.2024.107450<\/a>.<\/span><\/p>","protected":false},"featured_media":151,"parent":0,"template":"","news_cat":[4],"acf":[],"_links":{"self":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news\/732"}],"collection":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/media\/151"}],"wp:attachment":[{"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=732"}],"wp:term":[{"taxonomy":"news_cat","embeddable":true,"href":"https:\/\/igcore.thers.ac.jp\/en\/wp-json\/wp\/v2\/news_cat?post=732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}