{"id":744,"date":"2024-07-30T14:57:27","date_gmt":"2024-07-30T05:57:27","guid":{"rendered":"https:\/\/igcore.thers.ac.jp\/en\/?post_type=news&p=744"},"modified":"2024-07-30T14:57:27","modified_gmt":"2024-07-30T05:57:27","slug":"744-2","status":"publish","type":"news","link":"https:\/\/igcore.thers.ac.jp\/en\/news\/744-2.html","title":{"rendered":"Researchers create ADP- or ATP-containing molecules with improved yield and consistency"},"content":{"rendered":"

Adenosine diphosphate (ADP) or adenosine triphosphate (ATP)-containing important biological molecules can modify macromolecules like proteins and nucleic acids to alter their\u00a0function in the cell. Synthesizing ADP- and ATP-containing molecules using traditional methods is challenging, however. A new chemical reaction has greatly improved the\u00a0amount of synthesized ADP- and ATP-containing molecules created during a reaction, allowing researchers to use and better understand the function of these molecules in the\u00a0cell.
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Traditional methods of generating ADP- and ATP-containing molecules suffer many drawbacks, including complex procedures, drying conditions, low reproducibility and low\u00a0reaction yields. Additionally, many of these reactions can only accommodate a narrow range of molecules that can construct an ADP or ATP framework, limiting their usefulness.\u00a0
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To address this issue, a team of researchers developed a new chemical reaction that reliably produces ADP- and ATP-containing molecules with high yields. To do this, the team\u00a0modified a coupling reaction to create ADP- and ATP-containing molecules including nicotinamide adenine dinucleotide (NAD+, a molecule involved in energy metabolism)\u00a0analogs.\u00a0
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The team published the study in the July \/ 19th issue of\u00a0Chemistry: A European Journal.

News Release for this research:\u00a0https:\/\/www.eurekalert.org\/news-releases\/1052817<\/a><\/span><\/p>\r\n

\u3010Paper Information<\/span>\u3011
Rui Hagino, Ryo Kuwabara, Naoko Komura, Akihiro Imamura,\u00a0Hideharu Ishida, Hiromune Ando, Hide-Nori Tanaka.\u00a0
Protecting-Group-Free Synthesis of ADP-Ribose and\u00a0Dinucleoside Di-\/Triphosphate Derivatives via P(V)-P(V) Coupling\u00a0Reaction
Chemistry-A European Journal
DOI: 10.1002\/chem.202401302
URL:\u00a0https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.202401302<\/a><\/span><\/p>","protected":false},"featured_media":151,"parent":0,"template":"","news_cat":[4],"class_list":["post-744","news","type-news","status-publish","has-post-thumbnail","hentry","news_cat-paper"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\t