{"id":876,"date":"2026-06-12T13:11:25","date_gmt":"2026-06-12T04:11:25","guid":{"rendered":"https:\/\/igcore.thers.ac.jp\/en\/?post_type=news&#038;p=876"},"modified":"2026-06-12T13:11:25","modified_gmt":"2026-06-12T04:11:25","slug":"876-2","status":"publish","type":"news","link":"https:\/\/igcore.thers.ac.jp\/en\/news\/876-2.html","title":{"rendered":"A novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 regulates its secretion and enzyme activity"},"content":{"rendered":"<p><strong data-start=\"26\" data-end=\"141\">Professor Sato\u2019s Research Group Identifies ST8Sia5, a Novel Enzyme Responsible for Polysialic Acid Biosynthesis<\/strong><br data-start=\"141\" data-end=\"144\" \/><em data-start=\"144\" data-end=\"259\">New Insights into the Biological Significance of Polysialic Acid Associated with Psychiatric Disorders and Cancer<\/em><\/p>\r\n<p>The research findings of Professor Chihiro Sato and colleagues have been published in <em data-start=\"628\" data-end=\"665\">The Journal of Biological Chemistry<\/em>. The study reports the discovery of a novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 and reveals its role in regulating enzyme secretion and activity, providing new insights into the biological significance of polysialic acid.<\/p>\r\n<p class=\"isSelectedEnd\"><strong><span>[Publication Information]<\/span><\/strong><\/p>\r\n<p class=\"isSelectedEnd\"><strong><span>Journal:<\/span><\/strong><span> <\/span><em><span>The Journal of Biological Chemistry<\/span><\/em><\/p>\r\n<p class=\"isSelectedEnd\"><strong><span>Title: <\/span><\/strong><em><span>A novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 regulates its secretion and enzyme activity<\/span><\/em><\/p>\r\n<p class=\"isSelectedEnd\"><strong><span>Authors: <\/span><\/strong><span>Fumiya Sakamoto, Rina Hatanaka, Masaya Hane, Di Wu, Ken Kitajima, and Chihiro Sato<\/span><\/p>\r\n<p class=\"isSelectedEnd\"><strong><span>DOI: <\/span><\/strong><span>10.1016\/j.jbc.2026.113106<\/span><\/p>\r\n<p><strong><span>Article Link: <\/span><\/strong><a href=\"https:\/\/doi.org\/10.1016\/j.jbc.2026.113106\"><span>https:\/\/doi.org\/10.1016\/j.jbc.2026.113106<\/span><\/a><\/p>","protected":false},"featured_media":151,"parent":0,"template":"","news_cat":[4],"class_list":["post-876","news","type-news","status-publish","has-post-thumbnail","hentry","news_cat-paper"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/igcore.thers.ac.jp\/en\/news\/876-2.html\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/igcore.thers.ac.jp\\\/en\\\/news\\\/876-2.html#breadcrumblist\",\"itemListElement\":[{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/igcore.thers.ac.jp\\\/en#listItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/igcore.thers.ac.jp\\\/en\",\"nextItem\":{\"@type\":\"ListItem\",\"@id\":\"https:\\\/\\\/igcore.thers.ac.jp\\\/en\\\/news\\\/#listItem\",\"name\":\"NEWS &amp; 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