I am assistant professor in Laboratory of Animal Cell Function, iGCORE (Nagoya University). My research targets on CMP-sialic acid synthetase (CSS), which is prerequisite for the expression of sialic acid (Sia)-containing glycoproteins and glycolipids, because CSS only provides all kinds of sialyltransferases with a donor substrate CMP-Sia. My final goal is to understand the biological significance of CSS at organism level. For this purpose, medaka (mdk) fish was chosen as a vertebrate model, various mutant medaka with a single amino acid substitution in CSS and specific CSS-domain knock-out medaka were established. To understand how CSS regulate sialylation through specific amino acids and domains at organism level, morphological changes and sialylation changes in these CSS mutant medaka strains are studied by biochemical analysis, histological analysis and glycomic analysis.