Getting to the essence of life
At iGCORE, collaborative efforts in synthetic chemistry, single molecule imaging, and computational science are employed to elucidate the physical behaviors of individual glycan molecules. Additionally, our institute also studies the assembly state, localization, and co-localization principles of glycans with other molecules at the cellular level, using chemical biology and bioinformatics.
We are also developing new techniques to chemically, genetically regulate glycan assemblies through the development of glycan probes and inhibitors. Furthermore, by applying the principles of the behavior of single glycan molecules and glycan assemblies, as well as glycomics (comprehensive structural analysis of glycans), we aim to elucidate the functions of glycans in dynamic physiological processes such as development, aging, and diseases such as dementia, psychiatric disorders, cancer, infectious diseases, and more. Through our studies, we hope to gain a deeper understanding of the nature of life and advance new diagnostics and treatments for these diseases.