A research group led by Professor Yasuhiko Kizuka of the Institute for Glycobiology Core Research (iGCORE) has discovered a new mechanism of which cancer-related glycan biosynthesis.
GnT-V is an enzyme to synthesize cancer-related glycan. In this study, GnT-V was shown to exist in extracellular vesicles released by cancer cells and that these vesicles are passed directly to another cell. The cells that receive the vesicles begin to make new cancer-type glycans by GnT-V, indicating that the cellular glycans are modified through the delivery of the enzyme on the vesicles.
This research is expected to contribute to the elucidation of a new mechanism that regulates the synthesis of glycans and the mechanism of cancer progression via extracellular vesicles.
The research results were published in the international journal "iScience" on December 5, 2022.
Title: N-Acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells