Professor Sato’s Research Group Identifies ST8Sia5, a Novel Enzyme Responsible for Polysialic Acid Biosynthesis
New Insights into the Biological Significance of Polysialic Acid Associated with Psychiatric Disorders and Cancer
The research findings of Professor Chihiro Sato and colleagues have been published in The Journal of Biological Chemistry. The study reports the discovery of a novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 and reveals its role in regulating enzyme secretion and activity, providing new insights into the biological significance of polysialic acid.
[Publication Information]
Journal: The Journal of Biological Chemistry
Title: A novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 regulates its secretion and enzyme activity
Authors: Fumiya Sakamoto, Rina Hatanaka, Masaya Hane, Di Wu, Ken Kitajima, and Chihiro Sato
DOI: 10.1016/j.jbc.2026.113106
Article Link: https://doi.org/10.1016/j.jbc.2026.113106
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